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目的：观察活血通脉片（ＨＸＴＭＴ）对缺血再灌注所致Ｗｉｓｔａｒ大鼠心肌梗塞范围及血清肌酸磷酸激酶（ＣＰＫ）、乳酸脱氢酶（ＬＤＨ）、丙二醛（ＭＤＡ）、超氧化歧化酶（ＳＯＤ）活性的影响．方法：结扎大鼠冠状动脉左前降支，并使其实现再灌注；恢复自主呼吸２ｈ后，腹主动脉取血，测定血清ＣＰＫ、ＬＤＨ、ＭＤＡ、ＳＯＤ含量；采用多媒体彩色病理图文分析系统（ＭＰＩＡ－５００）以固定取像距离测量正常心肌及梗塞心肌面积．结果：活血通脉片两剂量组及阳性对照药恬尔心均能明显使心肌缺血再灌注心梗面积缩小（Ｐ＜０．０５～Ｐ＜０．０１ｖｓｍｏｄｅｌ），并对血清ＣＰＫ、ＬＤＨ、ＳＯＤ和ＭＤＡ含量有明显影响（Ｐ＜０．０５～Ｐ＜０．０１ｖｓｍｏｄｅｌ）．结论：活血通脉片为缺血性心脏病的治疗提供了重要依据．
OBJECTIVE: To observe the myocardial infarction scope and serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH), malondialdehyde (MDA) and superoxidation in Wistar rats induced by ischemia-reperfusion by Huoxue Tongmai tablet (HXTMT). The effect of dismutase (SOD) activity. METHODS: The left anterior descending coronary artery was ligated in rats and allowed to reperfuse. After 2 hours of spontaneous respiration, blood was taken from the abdominal aorta to determine the levels of serum CPK, LDH, MDA and SOD. The multimedia color pathology graphic analysis system was used. MPIA-500) Measure normal myocardium and infarcted myocardium area with a fixed imaging distance. RESULTS: Both Huoxue Tongmai Tablets and the positive control drug Jairol Heart both significantly reduced the myocardial ischemic reperfusion infarct size (P<0.05-P<0.01 vs model) and serum CPK, LDH, The contents of SOD and MDA were significantly affected (P<0.05-P<0.01 vs model). 5. Conclusion: Huoxue Tongmai Tablets provide an important basis for the treatment of ischemic heart disease.