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目的分析冠心病患者外周血中sCD14的水平及其与单核细胞数量的相关关系,探讨sCD14和动脉粥样硬化之间的关系。方法ELISA法测定269例冠心病患者和24例健康人血清中的sCD14水平,血细胞分析仪检测受试者抗凝全血中单核细胞的数目和比例。结果冠心病患者与健康对照组sCD14分别为:(3 011.4±1431.4)ng/L和(1 943.8±510.2)ng/L,二者结果有显著差异(t=3.7259,P=0.002);冠心病患者血清sCD14水平(Y)与血单核细胞数量(X)和比例(X)均无相关关系,直线回归方程分别为:Y=2 969.8-95.6X,r=-0.026,P=0.668;Y=2 763.6+1581.8X,r=0.060,P=0.329。结论冠心病患者血清sCD14水平显著性增高与血单核细胞数量和比例均无相关关系,可能与单核细胞的质量改变有关。
Objective To analyze the correlation between the level of sCD14 in peripheral blood and the number of mononuclear cells in patients with coronary heart disease and to explore the relationship between sCD14 and atherosclerosis. Methods Serum levels of sCD14 were measured in 269 patients with coronary heart disease and 24 healthy controls by ELISA. The number and proportion of mononuclear cells in anticoagulated whole blood of the subjects were detected by hematology analyzer. Results The sCD14 of CHD patients and healthy controls were (3 011.4 ± 1431.4) ng / L and (1943.8 ± 510.2) ng / L, respectively, with significant differences between the two groups (t = 3.7259, P = 0.002) There was no correlation between serum sCD14 level (Y) and the number of mononuclear cells (X) and ratio (X). The linear regression equations were Y = 2 969.8-95.6X, r = -0.026, P = 0.668; = 2 763.6 + 1581.8X, r = 0.060, P = 0.329. Conclusion Serum sCD14 levels in patients with coronary heart disease significantly increased the number and proportion of blood mononuclear cells were not related, may be related to changes in the quality of mononuclear cells.