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目的:观察复方经血停的药理作用,探讨其治疗青春期子宫出血的作用机制。方法:观察复方经血停对正常小鼠子宫、卵巢质量及血清雌二醇水平的影响,对去卵巢小鼠子宫质量的影响,对小鼠出血时间和凝血时间的影响,对大鼠离体子宫收缩功能的影响。结果:经血停能增加小鼠子宫和卵巢质量,能显著提高血清雌二醇水平;可增加去卵巢小鼠子宫质量;缩短小鼠出血时间和凝血时间;能显著增强大鼠离体子宫的收缩频率、幅度和活动力。结论:经血停可促进雌激素分泌,有雌性激素样作用,有止血、兴奋子宫平滑肌等作用。
OBJECTIVE: To observe the pharmacological effects of compound menstruum and to explore its mechanism of treatment of adolescent uterine bleeding. Methods: The effect of Fufang Mengying on the quality of uterus and ovary and the level of serum estradiol in normal mice were observed. The effects of compound menstruum on uterine quality of ovariectomized mice and the bleeding time and clotting time of mice were observed. Shrinkage effects. Results: Menstrual blood can increase the quality of uterus and ovary, can significantly increase the level of serum estradiol, increase the uterus quality of ovariectomized mice, shorten the bleeding time and clotting time of mice, and significantly increase the contraction of isolated uterus in rats Frequency, amplitude and activity. Conclusion: menstrual blood can promote the secretion of estrogen, estrogen-like effect, with hemostasis, excited uterine smooth muscle and so on.