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Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(=800 mgm(-2)h(-1)),and reduced DI(MTX)(=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-
Although high-dose methotrexate (HD-MTX) is the most effective drug against primary CNS lymphomas (PCNSL), outcome-de-termining variables related to its administration schedule have not been defined. The impact on toxicity and outcome of the area under thecurve (AUC (MTX)) and infusion rate (IR (MTX)) of MTX and plsamatic creatinine clearance (CL (crea)) were investigated in a retrospective series of 45 PCNSL patients treated with three different Age> 60 years, anticonvulsant therapy, slow IR (MTX) ( = 800 mgm (-2) h (-1)), and reduced DI (MTX) ( = 1000 mgm (-2) wk (-1)) were significantly correlated with low AUC