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目的通过对胃癌患者血清中微量元素铁、铜、锌的检测,探讨微量元素与胃癌发病的关系。方法采用分光光度法检测50例胃癌患者和50例健康对照者血清中Cu、Zn和Fe离子浓度,分析胃癌患者与健康对照者之间血清铜、锌和铁离子含量及铜/锌比值的差异,分析血清铜、锌和铁离子含量及铜/锌比值与胃癌临床病理参数之间的关系。结果(1)胃癌患者组血清铜、铜/锌比值均高于健康对照组(P<0.05或P<0.01);血清锌含量低于对照组(P<0.01),血清铁含量与对照组无统计学差异(P>0.05)。(2)初治胃癌患者血清铁含量高于非初治胃癌患者(P<0.01);血清锌、铜、铜/锌比2组相比无统计学差异(P>0.05)。(3)初治胃癌患者中低分化和未分化患者组血清锌含量低于高分化和中分化患者组(P<0.05),铜/锌比高于高分化和中分化患者组(P<0.05),而血清铜含量2组相比无统计学差异(P>0.05);浸润程度T3和T4患者组血清锌含量低于浸润程度T1和T2患者组(P<0.05),铜/锌比高于浸润程度T1和T2患者组(P<0.001),血清铜含量高于浸润程度T1和T2患者组(P<0.05);血清锌、铜、铜/锌比与病人的年龄、性别、肿瘤的大小、定位、淋巴结转移以及远处转移无关。结论(1)铜、锌等微量元素的含量异常与胃癌的发病存在内在的联系。(2)胃癌的病程发展也影响了铜、锌、铁等微量元素的含量异常。
Objective To investigate the relationship between trace elements and the incidence of gastric cancer by detecting the trace elements iron, copper and zinc in the serum of patients with gastric cancer. Methods The serum concentrations of Cu, Zn and Fe in 50 gastric cancer patients and 50 healthy controls were detected by spectrophotometry. The contents of copper, zinc and iron in serum and copper / zinc ratio in gastric cancer patients and healthy controls were analyzed. , The relationship between serum copper, zinc and iron ion content and copper / zinc ratio and clinicopathological parameters of gastric cancer were analyzed. Results The serum copper and copper / zinc ratio in gastric cancer patients were significantly higher than those in healthy controls (P <0.05 or P <0.01), serum zinc levels were lower than those in control group (P <0.01) Statistical difference (P> 0.05). (2) The serum iron level in newly diagnosed gastric cancer patients was higher than that in non-diagnosed gastric cancer patients (P <0.01). There was no significant difference in serum zinc, copper and copper / zinc between the two groups (P> 0.05). (3) Serum Zinc levels in patients with poorly differentiated and undifferentiated gastric cancer were lower than those in well-differentiated and moderately differentiated patients (P <0.05), and copper / zinc ratios were higher than those in well-differentiated and moderately differentiated patients (P <0.05) (P> 0.05). The levels of serum zinc in patients with T3 and T4 infiltration were lower than those in patients with infiltration T1 and T2 (P <0.05), and the ratio of copper to zinc was high (P <0.001), and the level of copper in serum was higher than that in patients with T1 and T2 infiltration (P <0.05). The serum levels of zinc, copper and copper / zinc were positively correlated with the age, sex, Size, location, lymph node metastasis and distant metastasis. Conclusions (1) The content of trace elements such as copper and zinc is intrinsically linked with the onset of gastric cancer. (2) The progression of gastric cancer also affected the content of copper, zinc, iron and other trace elements abnormalities.