患者男,71岁。因患糖尿病于2004年10月5日开始自行服用格列美脲,2mg/d口服,2周后感觉腹胀、乏力,停药10d。再次服用2周后又感觉腹胀,以进食后和夜间明显,乏力,面色蜡黄,尿黄,腹泻便秘交替发生,口中常有金属铜样异味感,食欲减退,继续服用2个半月后停药,观察10余天症状未好转,于2 Patient male, 71 years old. Due to diabetes on October 5, 2004 began to take their own glimepiride, 2mg / d orally, 2 weeks after feeling bloating, fatigue, withdrawal 10d. 2 weeks after taking another feeling of abdominal distension, after eating and night obviously, fatigue, looking sallow, urine yellow, diarrhea and constipation alternating mouth often smell of metallic copper-like smell, loss of appetite, continue taking 2 and a half months after withdrawal, Observed more than 10 days did not improve the symptoms, at 2