论文部分内容阅读
目的:探索虎杖苷(polydatin)对高盐饮食诱导的SD大鼠血压升高及血管功能损害的影响。方法:8周龄雄性Sprague Dawley(SD)大鼠40只,分正常对照组、模型组及虎杖苷高(150 mg/kg)、低(50 mg/kg)剂量组,每组10只大鼠,喂养过程中每周检测体质量、鼠尾收缩压,实验结束时取血测SOD、MDA、ET-1、NO,取胸主动脉检测血管反应性。结果:8%高盐饮食可使SD大鼠平均动脉压显著升高(P<0.01),150 mg/kg虎杖苷灌胃可显著对抗高盐饮食导致的血压升高,并可显著降低高盐介导的SD大鼠机体氧化应激水平的升高,降低ET-1,升高NO水平,对抗高盐介导的血管功能损害。结论:虎杖苷可对抗高盐饮食诱导的SD大鼠血压升高,并可能通过其抗氧化作用对抗高盐介导的血管功能损害,其确切机制有待进一步研究。
AIM: To investigate the effects of polydatin on blood pressure and vascular dysfunction induced by high-salt diet in SD rats. Methods: Forty male Sprague Dawley (SD) rats, 8 weeks old, were randomly divided into four groups: normal control group, model group and corticosteroid group with high dose of 150 mg / kg and low dose of 50 mg / Body weight and systolic blood pressure were measured every week during feeding. Blood samples were collected for determination of SOD, MDA, ET-1 and NO at the end of the experiment. Vascular reactivity was measured by thoracic aorta. Results: 8% high-salt diet significantly increased mean arterial pressure (P <0.01) in SD rats, while 150 mg / kg polydatin significantly inhibited the increase of blood pressure induced by high-salt diet and significantly decreased high salt Mediated SD rats increased oxidative stress, decreased ET-1, increased NO levels, and counteract the damage of high salt-mediated vascular dysfunction. CONCLUSION: Polydatin can antagonize the high blood pressure induced by high-salt diet in SD rats and may resist the salt-induced vascular dysfunction through its antioxidation. The exact mechanism remains to be further studied.