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目的:探讨男性老年人高血压病肾气亏虚证、肝火上炎证与性激素相关调控因素的关联性,从而为研究老年人高血压病肾气亏虚证、肝火上炎证证候表现的病理生理基础提供依据。方法:根据高血压诊断与分级标准、中医辨证标准选择了男性高血压病肾气亏虚证、肝火上炎证患者各30例和健康老年男性30例,采用酶联免疫吸附法检测白介素-2(IL-2)、瘦素(Leptin)、肿瘤坏死因子(TNF-α)、促性腺激素释放激素(GnRH)和硫酸脱氢表雄酮(DHEA-S)的水平。结果:男性老年人高血压肾气亏虚证患者的性激素相关调控因素水平的异常变化与男性老年人高血压病肾气亏虚证的发病有关,预示血清白介素-2、瘦素、促性腺激素释放激素和硫酸脱氢表雄酮水平的异常变化可能是男性老年人高血压病肾气亏虚证形成的病理基础之一。
OBJECTIVE: To investigate the association between the deficiency of kidney-qi deficiency syndrome, the inflammation of the liver and the regulation of sexual hormones in hypertension in the elderly, so as to study the syndrome of deficiency of kidney- Provide the basis for the pathophysiology. Methods: According to the diagnosis and grading standards of hypertension, TCM syndrome differentiation criteria were selected: 30 cases of Hypertension with Deficiency of Kidney-qi Deficiency Syndrome, 30 cases of Anhuo-Shang-Yan Syndrome, and 30 healthy elderly males. Enzyme-linked immunosorbent assay IL-2, Leptin, TNF-α, GnRH and DHEA-S were measured. Results: The abnormal changes of sex hormone related regulatory factors in hypertensive renal insufficiency syndrome in male elderly patients were related to the incidence of kidney deficiency syndrome of hypertension in male elders, indicating that serum interleukin-2, leptin, gonadotropin Abnormal changes in the levels of releasing hormone and dehydroepiandrosterone may be one of the pathological bases for the formation of kidney-qi deficiency syndrome in the elderly with hypertension.