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目的 探讨２型糖尿病患者血小板功能改变与血管病变的关系。方法同时测定６９例２型糖尿病患者和１４例正常人（Ｋ组）血小板ＡＤＰ聚集率和血小板表面颗粒膜蛋白（ＣＤ６２Ｐ和ＣＤ６３）表达的变化，并根据２４小时尿白蛋白排泄量将糖尿病患者分为正常白蛋白尿组（Ａ组）、微量白蛋白尿组（Ｂ组）和大量白蛋白尿组（Ｃ组）。结果与Ｋ组比较，Ｂ组和Ｃ组血小板ＡＤＰ％显著升高，Ｐ值分别小于０．０５和小于０．０１；Ａ组、Ｂ组和Ｃ组血小板表面ＣＤ６２Ｐ和ＣＤ６３表达阳性率，均显著升高，以Ｃ组最高；血小板ＡＤＰ聚集率与ＣＤ６２Ｐ和ＣＤ６３表达的阳性率呈显著正相关。结论２型糖尿病患者血小板聚集功能和活化功能显著增强，尤其在伴有白蛋白尿的患者中，并参与血管病变的发生和发展。
Objective To investigate the relationship between platelet function and vascular diseases in type 2 diabetic patients. Methods Sixty-nine patients with type 2 diabetes mellitus and 14 normal subjects (group K) were enrolled in the study. The ADP aggregation rate and the expression of granular membrane protein (CD62P and CD63) on platelets were measured simultaneously. According to 24-hour urinary albumin excretion, For the normal albuminuria group (A group), microalbuminuria group (B group) and a large number of albuminuria group (C group). Results Compared with K group, the ADP% of platelets in group B and group C were significantly increased, the P values were less than 0.05 and less than 0.01 respectively. The positive rates of CD62P and CD63 on platelets of group A, group B and group C were significant Increased to C group highest; platelet ADP aggregation rate and CD62P and CD63 expression positive rate was significantly positive correlation. Conclusion Platelet aggregation and activation in patients with type 2 diabetes are significantly increased, especially in patients with albuminuria and are involved in the occurrence and development of vascular lesions.