目的　探索复方大青叶注射液与复方氨基比林注射液配伍后的解热效果及毒性的变化。方法　采用化学刺激法使家兔致热后进行解热试验；按药典规定用小白鼠做异常毒性试验。结果　两药配伍降温效果减弱，起效慢，毒性增高。结论　此二种注射液有配伍禁忌，故不能配伍使用，建议临床纠正这一不合理的用药方案。 Objective To explore the antipyretic effect and toxicity of compound Daqingye injection combined with aminopyrine injection. Methods Antipyretic test was conducted after the rabbit was heated by chemical stimulation. According to the Pharmacopoeia, the mice were subjected to an aberrant toxicity test. Results The compatibility of the two drugs decreased, the onset was slow, and the toxicity increased. Conclusion These two injections have incompatibility and therefore cannot be used in combination. It is recommended to clinically correct this irrational drug regimen.