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目的观察联合应用血液灌流、机械通气和长托宁治疗重症有机磷中毒疗效。方法将60例重度有机磷农药中毒患者分为治疗组(联合应用血液灌流、机械通气和长托宁治疗)和对照组。对照组按照常规给予紧急洗胃、催吐导泻,并给予机械通气,阿托品及氯磷定等治疗。治疗组在通常治疗基础上应用血液灌流、机械通气和长托宁治疗。观察胆碱酯酶(CHE)恢复时间、长托宁和阿托品用量和给药次数、机械通气时间、昏迷时间、死亡率等指标。结果治疗组CHE恢复时间、长托宁用量和给药次数、机械通气时间、昏迷时间、死亡率等均显著低于对照组(P<0.05)。结论联合应用血液灌流、机械通气和长托宁治疗重症有机磷中毒疗效显著。
Objective To observe the curative effect of combined application of hemoperfusion, mechanical ventilation and penehyclidine on severe organophosphate poisoning. Methods Sixty patients with severe organophosphorus pesticide poisoning were divided into treatment group (combination of hemoperfusion, mechanical ventilation and treatment of penehyclidine) and control group. Control group according to the routine given emergency gastric lavage, induce vomiting and catharsis, and given mechanical ventilation, atropine and chlorpromazine treatment. The treatment group was treated with hemoperfusion, mechanical ventilation and penehyclidine on the basis of the usual treatment. Choline esterase (CHE) recovery time, the amount and administration of penehyclidine and atropine, mechanical ventilation time, coma time, mortality and other indicators were observed. Results The recovery time of CHE, the dosage and administration of penehyclidine, the duration of mechanical ventilation, the coma time and the mortality rate in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion The combination of hemoperfusion, mechanical ventilation and penehyclidine treatment of severe organophosphate poisoning has a significant effect.