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目的研究染色体易位与女性自然流产的关系。方法对2010年1月~2017年1月在我院妇产科门诊就诊的928例女性自然流产患者行外周血染色体核型分析。结果 928例女性遗传咨询者,共检出染色体易位24例,占2.59%,其中罗伯逊易位11例,相互易位13例,临床表现主要为自然流产。女性自然流产患者染色体易位检出率随着流产次数增加而增加,差异具有统计学意义(P<0.01)。结论染色体易位是导致女性自然流产发生的重要原因之一。
Objective To study the relationship between chromosomal translocations and female spontaneous abortion. Methods From January 2010 to January 2017 in our hospital obstetrics and gynecology clinic 928 cases of female spontaneous abortion patients with peripheral blood karyotype analysis. Results Among 928 female genetic counselors, 24 cases (2.59%) were detected chromosomal translocations, including Robertsonian translocation in 11 cases and translocation in 13 cases. The clinical manifestations were mainly spontaneous abortion. The detection rate of chromosomal translocation in women with spontaneous abortion increased with the increase of miscarriage frequency, the difference was statistically significant (P <0.01). Conclusion Chromosomal translocation is one of the important causes of spontaneous abortion in women.