Keloids are a notorious fibroproliferative disorder that may cause cosmetic concs and life inconvenience. Various methods such as surgery, injection, and laser have been used;however, single treatments are at risk of recurrence; therefore, comprehensive therapy is the better solution. Here, we focused on the management of different medical interventions according to subjective and objective conditions of keloid patients and summarized several clinical comprehensive strategies based on our clinical experience. One original concept of laser combined with radiotherapy was also introduced as a promising method, especially for wide-based pathological scars.