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目的探讨不同浓度利巴韦林对家兔外周血细胞的影响规律。方法将雄性家兔30只随机分为A、B、C、D、E5组,每组6只,分别注入利巴韦林5mg/kg、15mg/kg、25mg/kg、35mg/kg及注射生理盐水2ml,由家兔耳缘静脉缓慢推注,1次/d,7d为1个疗程,共2个疗程。分别在6个时间点观察家兔外周血RBC、Hb、网织红细胞(Ret)、WBC及Plt变化。结果RBC、Hb随着利巴韦林注射浓度增高而降低,而Ret明显上升,注射后第15天除A组外各组与E组比较差异均有统计学意义(均P<0.05);WBC除D组轻微降低(P<0.05)外余各组无明显变化(均P>0.05);Plt随着利巴韦林注射浓度升高而明显增多,注射后第15天除A、B组外各组Plt与E组比较差异均有统计意义(均P<0.05)。RBC、Hb、WBC及Plt在停药第15天后均能逐渐恢复至正常水平。结论利巴韦林可使家兔出现Plt增多和溶血,并随着利巴韦林浓度增高两者变化更为明显。
Objective To investigate the effects of different concentrations of ribavirin on rabbit peripheral blood cells. Methods Thirty male rabbits were randomly divided into three groups: A, B, C, D and E5, with 6 rats in each group. Ribavirin 5 mg / kg, 15 mg / kg, 25 mg / kg and 35 mg / Saline 2ml, rabbits ear vein slow injection, 1 / d, 7d for a course of treatment, a total of 2 courses. The changes of RBC, Hb, Ret, WBC and Plt in rabbit peripheral blood were observed at 6 time points respectively. Results RBC and Hb decreased with the increase of ribavirin concentration and Ret increased significantly. There was significant difference between group A and group E on the 15th day after injection (all P <0.05) There was no significant change in each group except the D group (P <0.05). Plt increased significantly with ribavirin injection. On the 15th day after injection, The difference between Plt and E groups was statistically significant (P <0.05). RBC, Hb, WBC and Plt in the withdrawal of 15 days after the gradual return to normal levels. Conclusion Ribavirin increased the number of Plt and hemolysis in rabbits, and the change of Ribavirin was even more obvious.