结直肠癌发病率高,人们对其预后甚为关注。过去60年中提出过不少与预后有关的因素,但尚无完美无缺者。本文从临床与病理学角度复习讨论与结直肠癌预后有关的问题。肿瘤侵袭范围是决定预后的重要因素。结直肠癌Dukes分期与生存期密切相关。其侵袭范围为:A期病灶限于肠壁;B期累及肠壁外组织而无淋巴结转移;C期有淋巴结转移,其中C_1期淋巴结限于局部,而C_2期达血管结扎平面;D期有远处转移。嗣后Kirklin等将其修改为:A期肿瘤限于粘膜,B_1期肿瘤累及固有肌层而B_2期穿透固有肌层,C期指B期伴淋巴结转移 The incidence of colorectal cancer is high, and people are very concerned about its prognosis. Many factors related to prognosis have been proposed in the past 60 years, but there are no perfect ones. This article reviews the issues related to the prognosis of colorectal cancer from a clinical and pathological point of view. The extent of tumor invasion is an important factor in determining the prognosis. Dukes stage and colorectal cancer are closely related to survival. The invasive range was: A stage lesion was limited to the intestinal wall; B stage involved extraintestinal tissue without lymph node metastasis; C stage had lymph node metastasis, in which C_1 lymph node was limited to local, and C_2 reached the vascular ligation plane; D stage had distant Transfer. Later, Kirklin et al. modified it to include: A-stage tumors were limited to the mucosa, B 1 tumors involved the muscularis propria, B 2 penetrated the muscularis propria, and C-phase B was associated with lymph node metastases.