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急性心肌梗塞后的左室再建可导致进行性左室扩张而增加病死率。Milrinone是一种磷酸二酯酶的抑制剂,具有正性心率和扩血管作用,亦可给左室功能紊乱的患者以症状上的缓解。作者的研究目的在于证实Milrinone是否能在急性心肌梗塞后改变左室的再建和防止进行性左室扩张。作者选用重200～225g(n=90)的SD大鼠,随机分成结扎左冠状动脉及假性手术两组,手术后3周给予Milrinone或不做处理,前者一直进行到处死前2天。术后90天在给容量负荷前后分别做血流动力学测量。杀死大鼠,取出心脏,作出被动充血下的压力——容积曲线。将心脏保持一定压力并作形态
Left ventricular remodeling after acute myocardial infarction can lead to progressive left ventricular dilatation and increase mortality. Milrinone, an inhibitor of phosphodiesterase, has positive heart rate and vasodilator effects and also provides symptomatic relief to patients with left ventricular dysfunction. The authors’ study aimed to demonstrate whether Milrinone can alter left ventricular remodeling and prevent progressive left ventricular dilatation after acute myocardial infarction. The authors selected SD rats weighing 200-225 g (n = 90) and were randomly divided into two groups: ligation of the left coronary artery and sham surgery. Milrinone was given 3 weeks after surgery and the treatment was continued until 2 days prior to sacrifice. Hemodynamic measurements were performed before and after the volume load for 90 days. Kill the rats, remove the heart and make a pressure-volume curve under passive congestion. The heart to maintain a certain pressure and shape