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目的分析武汉地区妇女子宫颈人乳头状瘤病毒(HPV)感染状况及其基因亚型的分布特征。方法以1211例妇女作为研究对象,采集其宫颈脱落细胞,采用导流杂交法(Hybri Max)进行HPV基因分型检测。结果 HPV阳性数255例,感染率为21.06%。人群中感染最多的亚型依次为HPV-52、16、58亚型,感染率构成比分别为15.69%、14.9%、10.98%。各年龄段中,18-20岁检出率最高(P<0.001)。结论武汉地区妇科就诊患者的HPV感染率较高,并且以高危型HPV感染为主,其中最常见的亚型是HPV-52。
Objective To analyze the distribution of cervical papillomavirus (HPV) infection and its subtypes in Wuhan women. Methods A total of 1211 women were enrolled in this study. Their exfoliated cells were collected and HPV genotyping was performed by Hybri Max. Results HPV positive number 255 cases, the infection rate was 21.06%. The most common subtypes in the population were HPV-52, 16 and 58 subtypes. The infection rates were 15.69%, 14.9% and 10.98%, respectively. Among all age groups, the highest detection rate was found in 18-20 years (P <0.001). Conclusions The prevalence of HPV infection in gynecologic gynecological patients in Wuhan is high, and high-risk type HPV infection is the most common. The most common subtype is HPV-52.