论文部分内容阅读
大肠癌治疗以综合治疗为主,化疗是其中主要手段之一,合理有效的化疗可以延长患者生存期,改善生活质量。化疗药物的研发已经从经验性的随机筛选转移到根据肿瘤发生机制定向的靶点研究,但由于存在个体遗传多态性,使患者对化疗药物的反应和毒性具有明显的个体差异,因此,化疗前对患者进行相关的基因检测,对临床合理选择用药有指导意义。
The treatment of colorectal cancer is mainly based on comprehensive treatment. Chemotherapy is one of the main means. The reasonable and effective chemotherapy can prolong the survival of patients and improve the quality of life. The development of chemotherapeutic drugs has shifted from empirical random selection to targeted studies based on the mechanism of tumorigenesis. However, due to the existence of individual genetic polymorphisms that have significant individual differences in the response and toxicity of chemotherapeutic drugs, chemotherapy Before the patient for genetic testing, the clinical rational choice of medication is instructive.