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目的 :探讨幽门螺旋杆菌 (Hp)感染性胃十二指肠疾病中胃泌素 (Gs)表达的临床意义及Hp感染与血清Gs水平的关系。方法 :用放射免疫分析对 4 6例Hp阳性患者及 33例Hp阴性的患者进行血清Gs测定 ,并观察Hp阳性患者Hp根除前后血清Gs的变化。 结果 :Hp阳性患者血清Gs的表达高于Hp阴性者 (p <0 0 5 ) ,Hp根除前血清Gs水平明显高于Hp根除后 (p <0 0 5 )。 结论 :Hp感染可引起血清Gs升高 ,Gs可作为Hp感染与否的一项指标
Objective: To investigate the clinical significance of gastrin (Gs) expression in Helicobacter pylori (Hp) infectious gastroduodenal diseases and the relationship between Hp infection and serum Gs level. Methods: Serum Gs was measured by radioimmunoassay in 46 Hp positive patients and 33 Hp negative patients, and the changes of serum Gs before and after Hp eradication were observed. Results: The expression of Gs in Hp positive patients was higher than that in Hp negative patients (p <0.05). The serum Gs level before Hp eradication was significantly higher than that after Hp eradication (p <0.05). Conclusion: Hp infection can cause elevated serum Gs, Gs can be used as an indicator of Hp infection or not