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目的明确检测血清癌抗原19-9(cancer antigen 19-9,CA19-9)、癌胚抗原(carcinoembryonic antigen,CEA)、癌抗原125(cancer antigen 125,CA125)在胰腺癌诊断及治疗过程中的作用及意义。方法采用回顾性分析的方法,对本院24例同步放化疗胰腺癌患者血清CA19-9、CEA及CA125进行相关比较,以明确联合检测对胰腺癌诊断的敏感度、治疗前血清标记物水平与临床分期及预后的关系、治疗前后血清肿瘤标记物变化程度与临床疗效及预后的关系。结果在胰腺癌诊断方面,CA19-9敏感度最高可达87.5%,若联合检测敏感度可达95.8%;治疗前各血清标记物水平与临床分期无关;治疗前CA19-9≥200 kU/L、CEA≥10μg/L、CA125≥50 kU/L者中位生存期明显短于CA19-9<200 kU/L、CEA<10μg/L、CA125<50 kU/L者,分别为8.0(1.4)个月vs 15.0(3.7)个月,6.0(1.8)个月vs12.0(1.7)个月,6.0(1.6)个月vs 12.0(5.6)个月(P<0.05或<0.01);而治疗前后任何异常血清标记物下降≥50%,其总缓解率为43.0%,疾病控制率为100%,中位生存期为12.0(3.2)个月。结论 CA19-9、CEA及CA125联合检测可提高胰腺癌诊断的敏感度,动态观察标记物的变化对判断疗效及预后有一定意义。
Objective To detect the expression of cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125) in the diagnosis and treatment of pancreatic cancer Role and significance. Methods A retrospective analysis of 24 patients with concurrent chemotherapy in patients with pancreatic cancer serum CA19-9, CEA and CA125 were compared to determine the combined detection of pancreatic cancer diagnosis sensitivity, serum markers before treatment and Clinical stage and prognosis, the changes of serum tumor markers before and after treatment and clinical efficacy and prognosis. Results The sensitivity of CA19-9 was up to 87.5% in the diagnosis of pancreatic cancer, and the sensitivity of combined detection was up to 95.8%. The level of serum markers was not related to clinical stage before treatment. Before treatment, CA19-9≥200 kU / L , CEA≥10μg / L, CA125≥50 kU / L, the median survival time was significantly shorter than CA19-9 <200 kU / L, CEA <10μg / Months vs 6.0 months vs 6.0 months vs 6.0 months vs 6.0 months vs 6.0 months vs 12.0 months vs 5.7 months A50% reduction in any abnormal serum marker with a total response rate of 43.0%, a disease control rate of 100%, and a median survival of 12.0 (3.2) months. Conclusion The combined detection of CA19-9, CEA and CA125 can improve the sensitivity of diagnosis of pancreatic cancer. The change of dynamic observation markers has some significance in judging the curative effect and prognosis.