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某些因素引起的内耳结构变化一、氨基糖苷类抗生素引起的内耳结构改变:(一)Harada 曾观察了氨基糖苷类抗生素药物对内耳前庭器官形态结构的损害。其结果,前庭器官感觉上皮受损严重。半规管壶腹嵴,特别是其中央部分感觉上皮变性,数月后减少。感觉毛融合直至消失,少数动物整个嵴上感觉毛可完全消失。椭圆囊斑可以出现同样的变化。鼓室内注射庆大霉素后二个月,嵴的感觉毛全部消失,嵴呈现皱缩。仅在嵴周缘部分感觉毛的表面有小泡样变化,纤毛的改变从变性到消失。在椭圆囊斑也有同样变化。腹膜腔内注射硫酸链霉素后其感觉毛的变化不及鼓室内注射快,二周组仅出现感觉毛稍微变化。4周组则壶腹嵴中央部分改变,感觉毛融合,
Changes in the structure of the inner ear caused by certain factors 1. Changes in the structure of the inner ear caused by aminoglycoside antibiotics: (1) Harada has observed the damage of the morphological structure of the vestibular organ of the inner ear by aminoglycoside antibiotics. As a result, the vestibular organ feels severely damaged epithelium. Semi-regulatory ampulla ridges, especially in the central part of the sensory epithelial degeneration, reduced after a few months. Feel hair fusion until disappear, a few animals feel the hair on the entire ridge can disappear completely. Ellipsoid spots can appear the same change. Two months after the tympanic injection of gentamicin, the sensation of the crest disappeared completely and the crest appeared to shrink. Only in the marginal part of the ridge feel the surface of hairy vesicle-like changes in cilia changes from denaturation to disappear. The same changes in the oval capsule plaque. The intraperitoneal injection of streptomycin sulfate sensation of hair less than the changes in the intratympanic injections, two weeks group only felt a slight change in hair. 4 weeks group is the central part of the ampulla changes, feeling hair fusion,