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目的 了解儿童肾病综合征 (NS)及糖皮质激素 (GC)治疗对血清胰岛素样生长因子 Ⅰ (IGF Ⅰ )及其结合蛋白(IGFBPs)的影响。方法 采用免疫放射法对 36名NS患儿 ,即未治疗的活动期组 (ANS ,12例 ) ,强的松治疗中活动期组 (GNS ,12例 )和缓解期组 (RE ,12例 ) ,进行了血清IGF Ⅰ及其IGFBPs水平测定 ,并以同年龄组正常儿童作对照 (NC ,10例 )。结果 (1)与正常对照比较 ,NS活动期血清IGF Ⅰ和IGFBP 3明显降低 (P <0 0 1) ,而IGFBP 1和IGFBP 2均明显升高 (P <0 0 1) ;(2 )NS缓解期血清IGF Ⅰ和IGFBP 3明显高于活动期 (P <0 0 1) ,而IGFBP 1和IGFBP 2明显低于活动期 (P <0 0 1) ;(3)经激素治疗的活动期组血清IGF Ⅰ和IGFBP 3均明显高于未治疗活动期组 (P <0 0 1) ,IGFBP 1和IGFBP 2水平也明显低于ANS组 (P <0 0 1) ;(4)NS活动期血清IGFBP 3与ALB成正相关 (r=0 76 ,P<0 0 1) ,血清IGF Ⅰ与IGFBP 3成正相关 ,而与IGFBP 1、IGFBP 2成负相关。在缓解期及激素治疗中的活动期血清IGF Ⅰ及IGFBPs与ALB及CHO没有相关关系。结论 1)儿童肾病综合征活动期血清IGF Ⅰ和IGFBPs发生明显改变 ,这种改变在缓解期可恢复正常。 2 )糖皮质激素治疗对肾病综合征儿童血清IGF Ⅰ和IGFBPs有明显影响。 3)肾病综合征儿童?
Objective To investigate the effects of treatment of children with nephrotic syndrome (NS) and glucocorticoid (GC) on serum insulin-like growth factor Ⅰ (IGF Ⅰ) and its binding proteins (IGFBPs). Methods Thirty-six NS children, 12 untreated active cases (ANS, 12 cases), 12 cases of active prednisone (GNS) and 12 cases of remission (RE) The levels of serum IGF Ⅰ and IGFBPs were measured and compared with normal children in the same age group (NC, 10 cases). Results (1) The levels of serum IGF Ⅰ and IGFBP 3 in NS active stage were significantly lower than those in normal control group (P <0.01), while IGFBP 1 and IGFBP 2 were significantly increased (P <0.01); (2) NS The levels of serum IGF Ⅰ and IGFBP 3 in remission stage were significantly higher than those in active stage (P <0.01), but IGFBP 1 and IGFBP 2 in remission stage were significantly lower than those in active stage (P 0 01). (3) Serum IGF Ⅰ and IGFBP 3 were significantly higher than those in untreated group (P <0.01), IGFBP 1 and IGFBP 2 levels were also significantly lower than those in ANS group (P <0.01); (4) Serum NS There was a positive correlation between IGFBP3 and ALB (r = 0 76, P <0.01). Serum IGF Ⅰ was positively correlated with IGFBP 3 and negatively correlated with IGFBP 1 and IGFBP 2. During remission and hormone therapy, there was no correlation between serum IGF Ⅰ and IGFBPs and ALB and CHO. Conclusion 1) Serum IGF Ⅰ and IGFBPs in children with active nephrotic syndrome significantly change, this change in the remission period can return to normal. 2) glucocorticoid treatment of children with nephrotic syndrome serum IGF Ⅰ and IGFBPs have a significant effect. 3) Nephrotic syndrome children?