论文部分内容阅读
Granule-mediated cytotoxicity is the major mechanism for lymphocytes to kill viruses,intracellular bacteria andtumors.The cytotoxic granules move to the immunological synapse by exocytosis after recognition of a killer cell.The contents of the granules are delivered into target cells with the help of perforin by endocytosis.A group ofserine protease granzymes cleave their critical substrates to initiate DNA damage and cell death.The mostabundant granzymes are granzyme A and B.They induce cell death through alternate and nonoverlappingpathways.The substrates and functions of the majority of the orphan granzymes have not yet been identified.It ispossible that the diversity of granzymes provides fail-safe mechanisms for killing viruses and tumor cells.Cellular& Molecular Immunology.2005;2(4):259-264.
Granule-mediated cytotoxicity is the major mechanism for lymphocytes to kill viruses, intracellular bacteria and tumors. The cytotoxic granules move to the immunological synapse by exocytosis after recognition of a killer cell. The contents of the granules are delivered into target cells with the help of perforin by endocytosis. A group of serine protease granzymes cleaver their critical substrates DNA and cell death. The mosplant of granzymes are granzyme A and B. They induce cell death through alternate and nonoverlapping pathways. These substrates and functions of the majority of the orphan granzymes have not yet been identified. It ispossible to the diversity of granzymes provides fail-safe mechanisms for killing viruses and tumor cells. Cellular & Molecular Immunology. 2005; 2 (4): 259-264.