目的　探讨低分子肝素对原发性肾病综合征的治疗作用。方法　将 68例肾病综合征随机分为两组 ,治疗组 3 8例采用低分子肝素结合糖皮质激素 ,并与对照组 3 0例单独使用糖皮质激素的患者进行疗效对比分析。结果　治疗组在降低尿蛋白 ,血浆白蛋白水平的恢复以及改善肾功能指标 (肌酐 ) ,降低血脂及血液高粘状态等方面明显优于对照组 ,P均<0 .0 5。结论　使用低分子肝素结合糖皮质激素是治疗原发性肾病综合征的有效方法 Objective To investigate the therapeutic effect of low molecular weight heparin on primary nephrotic syndrome. Methods 68 cases of nephrotic syndrome were randomly divided into two groups. The treatment group, 38 cases using low molecular weight heparin combined with glucocorticoid, and the control group, 30 cases of glucocorticoid alone were compared. Results The treatment group was significantly better than the control group in reducing urinary protein and plasma albumin levels, improving renal function (creatinine), reducing blood fat and blood viscosity, P <0.05. Conclusion Low molecular weight heparin combined with glucocorticoid is an effective treatment for primary nephrotic syndrome