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目的研究婴幼儿重症肺炎治疗前后潮气呼吸肺功能及D-二聚体的变化。方法以周口市中医院2012年3月至2014年3月收治的50例重症肺炎患儿为研究组,均接受吸氧、强心、抗感染等治疗,测定并比较患儿治疗前后潮气呼吸肺功能及D-二聚体水平,同时与同期行健康体检的50例正常婴幼儿(对照组)进行比较。结果研究组治疗前后呼吸频率(RR)、潮气量(VT)、吸气时间(TI)、呼气时间(TE)、达峰时间(至呼气峰流速时间,TPTEF)、达峰时间比(达峰时间/呼气时间,TPTEF/TE)、达峰容积比(达峰容积/呼气容积,VPTEF/VE)指标变化显著(P<0.01);研究组治疗前上述指标均与对照组比较差异有统计学意义(P<0.01);研究组治疗后TPTEF、TPTEF/TE、VPTEF/VE均仍明显低于对照组(P<0.01)。另外,研究组治疗前D-二聚体水平为(1.85±1.36)mg/L,与治疗后、对照组[(0.21±0.11)、(0.20±0.10)mg/L]比较差异均有统计学意义(P<0.01)。结论潮气呼吸肺功能及D-二聚体检测可作为婴幼儿重症肺炎病情程度、治疗效果评价的重要指标。
Objective To study the changes of pulmonary function and D-dimer before and after treatment of infantile severe pneumonia. Methods Fifty patients with severe pneumonia admitted from March 2012 to March 2014 in Zhoukou Hospital of Traditional Chinese Medicine were enrolled in this study. All patients were treated with oxygen, cardiac and anti-infective therapy. Function and D-dimer levels were compared with 50 normal infants (control group) who underwent physical examination in the same period. Results The changes of respiratory rate (RR), tidal volume (VT), inspiratory time (TI), expiratory time (TE), peak time to expiratory flow time (TPTEF) and peak time ratio Peak time / expiration time, TPTEF / TE), and peak volume ratio (peak volume / expiratory volume, VPTEF / VE) were significantly different (P <0.01); The study group before treatment were compared with the control group (P <0.01). The levels of TPTEF, TPTEF / TE and VPTEF / VE in the study group were still significantly lower than those in the control group (P <0.01). In addition, the D-dimer level in the study group before treatment was (1.85 ± 1.36) mg / L, which was statistically different from that in the control group [(0.21 ± 0.11) and (0.20 ± 0.10) mg / L] Significance (P <0.01). Conclusion Tidal respiratory function and D-dimer testing can be used as an important indicator of the severity of severe pneumonia in infants and young children and the evaluation of therapeutic effect.