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Doyne(1889)首次描述了眼底血管样条纹,最初认为该条纹从视乳头周围呈放射状延伸至周边眼底,参差不齐,貌似血管,故Knapp(1892)首先命名为血管样条纹。1916年Kofler才正确地解释了血管样条纹位于Bruch膜,1938年和1939年分别由Bock和Hagedoorn在2例患者的组织病理标本上予以证实。这些组织病理所见后来又在伴有弹性纤维假黄瘤与畸形性骨炎(Paget病)中以及不伴有全身病的眼底血管样条纹患者中得到证实。眼底血管样条纹伴发全身情况的有:肢端肥大症、Ehlers-Danlos综合征、糖尿病、颜面血管瘤病、血色素沉着症、后天性溶血性贫
Doyne (1889), for the first time, described a retinal vascular stripe originally thought to extend radially around the optic nerve to the peripheral ocular fundus, jagged, and looks like a blood vessel, so Knapp (1892) first named it as a blood vessel-like stripe. In 1916, Kofler correctly explained that the blood vessels were located on the Bruch’s membrane and were confirmed by histopathological examination in two patients in 1938 and 1939 respectively by Bock and Hagedoorn. These histopathologic findings were subsequently confirmed in patients with pseudotaxis of elastic fibers and Paget’s disease of the ankylosing spondylitis, as well as in patients with fundus stripe-like stria without systemic disease. Fundus vascular stripe associated with systemic conditions are: acromegaly, Ehlers-Danlos syndrome, diabetes, facial hemangiomatosis, hemochromatosis, acquired hemolytic lean