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目的:考察非聚氯乙烯(NPVC)多层共挤膜输液袋、聚丙烯(PP)输液瓶和玻璃瓶3种材质输液容器对氟尿嘧啶的吸附性。方法:将一定量的氟尿嘧啶加入3种包装材质输液中,与输液混合均匀后分别于0,6,24,48h取样,采用高效液相色谱法测定药物浓度。结果:48h相对0h的药物含量百分数:①在PP输液瓶中,氟尿嘧啶含量在82.95%～94.9%之间;②在玻璃瓶中氟尿嘧啶含量在96.59%～101.26%之间;③在NPVC输液袋中氟尿嘧啶含量在98.30%～100.19%之间。结论:PP输液瓶对氟尿嘧啶有吸附性,临床使用该药时避免选用该材质输液瓶,若不能避免选用,应考虑适当增加剂量。
OBJECTIVE: To investigate the adsorption of fluorouracil by three kinds of infusion containers of non-polyvinyl chloride (NPVC) multi-layer coextrusion film infusion bags, polypropylene infusion bottles and glass bottles. Methods: A certain amount of fluorouracil was added into the infusion solution of three kinds of packaging materials. After mixed with the infusion solution, samples were taken at 0, 6, 24 and 48 hours, respectively, and the drug concentration was determined by high performance liquid chromatography. Results: The percentages of drug content in 48 h relative to 0 h were as follows: (1) In the infusion bottles of PP, the content of fluorouracil was between 82.95% and 94.9%; (2) The content of fluorouracil in the glass bottles was between 96.59% and 101.26%; Fluorouracil levels ranged from 98.30% to 100.19%. CONCLUSION: The PP infusion bottle has the ability to adsorb fluorouracil. When the drug is used clinically, the infusion bottle should be avoided. If it can not be avoided, an appropriate dosage should be considered.