作者选择5例男性急性恶性疟或间日疟患者作为观察对象。患者年龄16～55岁,体重47～78kg,均有2～5天持续发热史,体温为37.6～40℃。所有患者近期未用任何抗疟药,亦无脑、肾及其他并发症。患者在开始用氯喹治疗前先静脉注射罗利环素500mg,静注时间在5分钟以上。氯喹双磷酸盐的首次剂量为15mg/kg(9mg基质/kg)。药物溶解在500ml生理盐水中静脉滴注4小时以上。继之在12、24、36以及60小时时再分别给于 The authors selected 5 male patients with acute falciparum or vivax malaria as subjects. Patients aged 16 to 55 years old, weighing 47 to 78kg, 2 to 5 days have a history of fever, body temperature 37.6 ~ 40 ℃. All patients have not used any anti-malaria drugs recently, and no brain, kidney and other complications. Patients before beginning treatment with chloroquine intravenous rolyrin 500mg, intravenous infusion time in more than 5 minutes. The first dose of chloroquine bisphosphate was 15 mg / kg (9 mg substrate / kg). Drug dissolved in 500ml saline intravenous infusion of more than 4 hours. Followed by 12, 24, 36, and 60 hours respectively