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在7例淋巴瘤病人中随机一次给予别嘌呤醇300mg口服或灌肠,给药前和给药后1,2,3,4,8以及24小时采血,经高压液相色谱仪检验血浆别嘌呤醇及其主要代谢产物别黄嘌呤浓度。3例口服患者于用药后1—2小时达最高血浓度,为3.5—6.6μg/ml。消除半衰期为2.3±1.3小时。4例经直肠给药患者血浆内未能检测出别嘌呤醇,另一例灌肠剂量达1050mg者也未测出。结果提示以本研究中应用之剂型经直肠给药吸收甚微,不能取代口服而为临床应用。
All 7 patients with lymphoma randomized to allopurinol 300mg orally or enema, before and after administration of 1,2,3,4,8 and 24 hours after administration of blood, high-pressure liquid chromatography test plasma allopurinol And its major metabolite xanthine concentration. 3 cases of oral patients in the 1-2 hours after treatment reached the highest blood concentration of 3.5-6.6μg / ml. Elimination half-life of 2.3 ± 1.3 hours. Four cases of rectal administration failed to detect allopurinol in plasma, another case of enema dose of 1050 mg was not detected. The results suggest that the formulations used in this study rectally administered little absorption, can not replace oral and clinical applications.