Full factorial design was used to evaluate the two-body abrasive resistance of 3wt%C–4wt%Mn–1.5wt%Ni spheroidal carbide cast irons with varying vanadium(5.0wt%–10.0wt%) and chromium(up to 9.0wt%) contents. The alloys were quenched at 920°C. The regression equation of wear rate as a function of V and Cr contents was proposed. This regression equation shows that the wear rate decreases with increasing V content because of the growth of spheroidal VC carbide amount. Cr influences the overall response in a complex manner both by reducing the wear rate owing to eutectic carbides(M_7C_3) and by increasing the wear rate though stabilizing austenite to deformation-induced martensite transformation. This transformation is recognized as an important factor in increasing the abrasive response of the alloys. By analyzing the regression equation, the optimal content ranges are found to be 7.5wt%–10.0wt% for V and 2.5wt%–4.5wt% for Cr, which corresponds to the alloys containing 9vol%–15vol% spheroidal VC carbides, 8vol%–16vol% M_7C_3, and a metastable austenite/martensite matrix. The wear resistance is 1.9–2.3 times that of the traditional 12wt% V–13wt% Mn spheroidal carbide cast iron. Full factorial design was used to evaluate the two-body abrasive resistance of 3 wt% C-4 wt% Mn-1.5 wt% Ni spheroidal carbide cast irons with varying vanadium (5.0 wt% -10.0 wt%) and chromium (up to 9.0 wt% ) contents. The alloys were quenched at 920 ° C. The regression equation of wear rate as a function of V and Cr contents was proposed. This regression equation shows that the wear rate decreases with increasing V content because of the growth of spheroidal VC carbide amount. Cr influences the overall response in a complex manner both by reducing the wear rate due to eutectic carbides (M_7C_3) and by increasing the wear rate though stabilizing austenite to deformation-induced martensite transformation. This transformation is recognized as an important factor in increasing The abrasive response of the alloys. By the regression equation, the optimal content ranges are found to be 7.5 wt% -10.0 wt% for V and 2.5 wt% -4.5 wt% for Cr, which corresponds to the alloys containing 9 vol% 15 vol% spheroidal VC carbides, 8 vol% -16 vol% M_7C_3, and a metastable austenite / martensite matrix. The wear resistance was 1.9-2.3 times that of the traditional 12 wt% V-13 wt% Mn spheroidal carbide cast iron.