早在一个世纪前,血管生成研究的先驱者发现人类肿瘤的生长总是伴随血管生成的增加。1863年病理学家Virchow在其著作《Die Krankhaften Gresch Wulste》中描述了肿瘤具有丰富血管的现象[1]。20世纪40年代,一些研究人员已经认识到 A century ago, pioneers of angiogenesis studies found that the growth of human tumors was always accompanied by an increase in angiogenesis. In 1863, the pathologist Virchow described the phenomenon of tumor-rich blood vessels in his book “Die Krankhaften Gresch Wulste” [1]. In the 1940s, some researchers have realized