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目的观察比较甘精胰岛素与中性鱼精蛋白锌胰岛素治疗2型糖尿病患者“黎明现象”的疗效。方法将60例符合黎明现象的2型糖尿病患者随机分成2组,A组30例,晚上2点皮下注射甘精胰岛素;B组30例,同样时间皮下注射中性鱼精蛋白锌胰岛素。观察血糖控制情况,血糖达标时间,每日胰岛素用量及低血糖发生情况。结果 2组均能有效治疗2型糖尿病患者黎明现象,且两组的低血糖事件发生次数相似。结论甘精胰岛素与中性鱼精蛋白锌胰岛素都可以更好地控制2型糖尿病患者的黎明现象,而且低血糖事件发生次数少,无严重低血糖事件发生。
Objective To observe the effect of insulin glargine and neutral protamine zinc insulin on type 2 diabetic patients with “dawn phenomenon”. Methods Sixty patients with type 2 diabetes who met the dawn were randomly divided into two groups. Group A (30 cases) received insulin glargine subcutaneously at 2 o’clock in the evening. Group B (30 cases) received subcutaneous injection of neutral protamine zinc insulin at the same time. Observed blood glucose control, blood glucose compliance time, daily dosage of insulin and hypoglycemia. Results Both groups were effective in treating dawn in type 2 diabetic patients, and the frequency of hypoglycemic episodes in both groups was similar. Conclusion Both glargine and neutral protamine zinc insulin can better control dawn in patients with type 2 diabetes, and the incidence of hypoglycemic events is low and no serious hypoglycemic events occur.