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目的:探讨醒脑静注射液对急性脑梗死(ACI)血瘀证患者外周血单个核细胞(PBMC)T淋巴细胞的影响。方法:70例患者随机分为治疗组以及对照组各35例。对照组用常规治疗,治疗组在常规治疗基础上加醒脑静注射液。疗程均为14 d,观察两组患者治疗前后中医疗效和NIHSS评分,检测治疗前及治疗后Th1、Th2百分率和Th1/Th2比值。结果:治疗组和对照组治疗前Th1、Th2百分率、Th1/Th2和NIHSS评分比较差异无统计学意义(P>0.05);治疗3、7、14 d后两组患者NIHSS评分与治疗前比较,均有统计学差异(P<0.05)。治疗组患者Th1、Th1/Th2、NIHSS评分在治疗后3、14 d均明显低于对照组(P<0.05),Th2以及中医疗效总有效率明显高于对照组(P<0.05或0.01)。结论:醒脑静注射液明显调控急性脑梗死血瘀证患者Th1/Th2平衡,对神经功能缺损具有较好的改善作用。
Objective: To investigate the effect of xingnaojing injection on T lymphocytes of peripheral blood mononuclear cells (PBMC) in patients with acute cerebral infarction (ACI) with blood stasis syndrome. Methods: Seventy patients were randomly divided into treatment group and control group of 35 cases. The control group with conventional treatment, the treatment group on the basis of conventional therapy plus Naocaojing injection. The duration of treatment was 14 days. The curative effect and NIHSS score of both groups before and after treatment were observed. The Th1, Th2 percentage and Th1 / Th2 ratio were measured before and after treatment. Results: There was no significant difference in the Th1, Th2, Th1 / Th2 and NIHSS scores between the two groups before and after treatment (P> 0.05). After 3, 7 and 14 days of treatment, There was statistical difference (P <0.05). The scores of Th1, Th1 / Th2 and NIHSS in the treatment group were significantly lower than those in the control group on the 3rd and 14th days after treatment (P <0.05), and the total effective rates of Th2 and TCM were significantly higher than those in the control group (P <0.05 or 0.01). Conclusion: Xingnaojing injection significantly regulates the balance of Th1 / Th2 in patients with blood stasis syndrome of acute cerebral infarction, and has a better effect on neurological deficits.