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目的探讨慢性心力衰竭患者心肌热休克蛋白47(HSP47)的表达及其与某些因素的相关性。方法 60例手术患者,采用实时荧光定量(RT-PCR)方法检测心肌HSP47的mRNA表达量。结果 HSP47mRNA在慢性心力衰竭患者中均有表达,且随心功能的下降HSP47表达升高。1慢性心力衰竭患者心肌HSP47与左室舒张末期内径呈独立、显著的正相关(r=0.785,P<0.05),与左室射血分数呈负相关(r=-0.804,P<0.05);2HSP47与年龄、血脂等无相关关系。结论慢性心力衰竭患者心肌HSP47表达随心功能下降而升高,与左室舒张末期内径呈正相关,而与左室射血分数呈负相关。
Objective To investigate the expression of heat shock protein 47 (HSP47) and its relationship with some factors in patients with chronic heart failure. Methods 60 cases of surgical patients, using real-time fluorescent quantitative (RT-PCR) method to detect myocardial HSP47 mRNA expression. Results HSP47mRNA was expressed in patients with chronic heart failure, and HSP47 expression was increased with the decrease of cardiac function. There was a significant positive correlation between myocardial HSP47 and left ventricular end - diastolic diameter in patients with chronic heart failure (r = 0.785, P <0.05), and a negative correlation with left ventricular ejection fraction (r = -0.804, P <0.05). 2HSP47 and age, blood lipids and other related. Conclusions The expression of HSP47 in patients with chronic heart failure is increased with the decrease of cardiac function, positively correlated with the end-diastolic diameter of left ventricle, and negatively correlated with left ventricular ejection fraction.