目的研究肿瘤坏死因子α（ＴＮＦα）和表皮生长因子（ＥＧＦ）对人、牛晶状体上皮细胞增殖的影响。方法采用ＭＴＴ比色法检测ＴＮＦα和ＥＧＦ对晶状体上皮细胞（ｌｅｎｓｅｐｉｔｈｅｌｉａｌｃｅｌ，ＬＥＣ）增殖的作用。结果０．１Ｕ／ｍｌ的ＴＮＦα即可明显促进人、牛晶状体上皮细胞的增殖；ＥＧＦ为１、１０ｎｇ／ｍｌ时可明显促进牛晶状体上皮细胞增殖。结论细胞因子ＴＮＦα、ＥＧＦ通过促进ＬＥＣ的增殖参与后囊混浊的形成 Objective To study the effects of tumor necrosis factor α (TNFα) and epidermal growth factor (EGF) on the proliferation of human and bovine lens epithelial cells. Methods The effects of TNFα and EGF on the proliferation of lens epithelial cells (lensepithelialcel, LEC) were detected by MTT assay. Results 0.1U / ml of TNF @ can significantly promote the proliferation of human, bovine lens epithelial cells; EGF 1,10 ng / ml can significantly promote the proliferation of bovine lens epithelial cells. Conclusions Cytokine TNF @, EGF involved in the formation of posterior capsule opacity by promoting the proliferation of LEC