目的探讨胃癌根治术后胃瘫综合征(PGS)的危险因素。方法收集260例胃癌根治术患者,根据术后是否发生PGS分为试验组(21例)和对照组(239例),比较两组患者的临床资料,并将具有统计学差异的因素进行多因素Logistic回归分析。结果两组患者在年龄、合并基础疾病、术前幽门梗阻、精神因素、胃肠吻合方式、手术时间、术中出血量、术后每日补液量和术后肠内营养开始时间等方面比较,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,术前幽门梗阻、合并基础疾病、手术时间长、B-Ⅱ式吻合和不良心理因素等为胃癌根治术后PGS发生的独立危险因素(P<0.05)。结论胃癌根治术后发生PGS的相关因素较多,对于术前幽门梗阻、合并基础疾病、手术时间较长、术中采用B-Ⅱ式吻合和不良心理因素的患者应给予高度重视,及时采取相应干预措施,以降低PGS的发生率。 Objective To investigate the risk factors of gastric paralysis syndrome (PGS) after radical operation of gastric cancer. Methods A total of 260 patients undergoing radical gastrectomy were enrolled in this study. According to whether postoperative PGS occurred or not, 21 patients in the experimental group and 239 patients in the control group were enrolled in this study. The clinical data of the two groups were compared and statistically significant factors were evaluated by multiple factors Logistic regression analysis. Results The two groups were compared in terms of age, underlying diseases, pyloric obstruction before surgery, mental factors, gastrointestinal anastomosis, operation time, intraoperative blood loss, postoperative daily fluid volume and postoperative enteral nutrition start time, The difference was statistically significant (P <0.05). Logistic regression analysis showed that preoperative pyloric obstruction, combined with underlying diseases, long operation time, B-Ⅱ anastomosis and adverse psychological factors were independent risk factors for PGS after radical operation of gastric cancer (P <0.05). Conclusion There are many related factors of PGS after radical gastrectomy in gastric cancer. For patients with preoperative pyloric obstruction, complicated underlying diseases, long operation time, B-Ⅱ anastomosis and adverse psychological factors in operation, patients should be given timely attention Interventions to reduce the incidence of PGS.