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目的 观察25 G微创玻璃体切除联合内界膜剥除及玻璃体腔注射曲安奈德与玻璃体腔注射10％ C3F8治疗特发性黄斑前膜的临床疗效.方法 选取2014年3月至2015年2月我院特发性黄斑前膜56例(56眼).随机分成两组,其中观察组28例,行25 G微创玻璃体切除联合内界膜剥除及玻璃体腔注射曲安奈德;对照组28例,行25 G微创玻璃体切除联合内界膜剥除及玻璃体腔注射10％ C3F8.检查术前、术后7d、1、3、6个月最佳矫正视力(BCVA)、黄斑中心区厚度(CMT)及眼压.结果 术后随访6个月,随访末期两组BCVA较术前显著提高,差异有统计学意义(P＜0.05),术后7d、1、3、6个月BCVA两组之间差异无统计学意义(P＞0.05).随访末期两组CMT较术前显著降低,差异有统计学意义(P＜0.05),术后7d、1、3、6个月两组之间CMT差异无统计学意义(P＞0.05).术前、术后7d、1、3、6个月两组之间眼压差异均无统计学意义(P＞0.05).结论 治疗特发性黄斑前膜时采用25 G微创玻璃体切除联合内界膜剥除术及玻璃体腔注射曲安奈德或10％ C3Fs均能提高视力、降低黄斑中心区厚度,改善黄斑水肿,两者的临床疗效差异无统计学意义.“,”Objective To observe the clinical efficacy of 25 G minimally invasive vitrectomy combined with internal limiting membrane peeling and intravitreal injetion of triamcinolone acetonide (TA) or 10％ C3Fs.Methods Fifty-six eyes of 56 cases with idiopathic macular epitetinal membrane in our hospital from March 2014 to February 2015 were enrolled.The patients were randomly divided into observation group and control group,each group contained 28 eys of 28 cases.All patients underwent 25 G minimally invasive vitrectomy combined with internal limiting membrane peeling.The observation group received combined surgery with intravitreal TA injection and the control group received combined surgery with weth intravitreal injection of 10％ C3F8.The best corrected visual acuity (BCVA),the central macular thickness (CMT) and intraocular pressure (IOP) were examined before surgery and 7 d,1,3 and 6 months after operation.Results Followed up for 6 months,at the end of the follow-up period,two groups of patients with BCVA significantly improved compared with the preoperative,the difference was statistically significant (P ＜ 0.05).The difference in BCVA of 7 d,1,3 and 6 months after operation was not significant between the two groups (P ＞ 0.05).Two groups of patients with CMT revealed a significant decrease with significant difference (P ＜ 0.05).CMT of 7 d,1,3 and 6 months after operation was no significant difference between the two groups (P ＞ 0.05).There was no significant difference in IOP between the two groups at preoperatively or 7 d,1,3 or 6 months (P ＞ 0.05).Conclusion For the treatment of idiopathic macular epiretinal membrane,the surgery 25 G minimally invasive vitrectomy combined with internal limiting membrane peeling in operation and intravitreal injection of TA or 10％ C3F8 can improve visual acuity,lower central fovea thickness,relieve the macular edema.There was no difference in the clinical efficacy between the two methods.