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目的 :研究输血传递病毒 (TTV)在不同类型肝病患者中的感染情况及非甲 庚型 (NA G)肝炎中TTV是否为肝炎的致病因子。方法 :采用nest PCR技术对临床上 12 9例肝病患者及反复输血的血液病患者血清检测了TTV DNA。ELISA法检测血清抗HAV IgM ,HBV M ,抗HCV IgG ,抗HEV IgM ,抗HGV -IgM及血清ALT水平。结果 :12 9例血清中TTV检出率为 19.38% (2 5 / 12 9)。 45例NA G型肝炎患者中检出率为 42 .2 2 % (19/45 ) ,其中急性肝炎 9例 ,慢性肝炎 9例 ,肝硬化 1例 ,肿功均有程度不同的损害。结论 :TTV感染是部分NA G型肝炎患者的致病因子 ,可导致慢性化。除输血传播外尚有肠道传播的可能性。
Objective: To investigate whether the infection of transfusion transmitted virus (TTV) in patients with different types of liver diseases and whether TTV is the causative agent of hepatitis in non-G G hepatitis. Methods: TTV DNA was detected by nest PCR in the sera of 129 patients with liver disease and those with blood transfusion repeatedly. Serum anti-HAV IgM, HBV M, anti-HCV IgG, anti-HEV IgM, anti-HGV-IgM and serum ALT were detected by ELISA. Results: The detection rate of TTV in 12 9 cases was 19.38% (2 5/129). The detection rate of 45 cases of NA hepatitis G was 42.22% (19/45), including 9 cases of acute hepatitis, 9 cases of chronic hepatitis and 1 case of liver cirrhosis. CONCLUSIONS: TTV infection is a causative agent of some patients with NA G-type hepatitis and can lead to chronicity. In addition to blood transfusion there is the possibility of intestinal transmission.