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目的 :研究分析手术结合新辅助化疗治疗颈腰部侵袭性纤维瘤病的临床治疗效果。方法 :选取2012年8月~2013年6月在我院接受治疗的21例颈腰部侵袭性纤维瘤病患者为单纯手术组(只接受手术治疗),另选取2013年8月至2014年6月在我院接受治疗的21例颈腰部侵袭性纤维瘤病患者为联合组(接受手术结合新辅助化疗治疗),对两组患者均进行为期20个月的随访调查。将两组临床疗效、复发情况,治疗前、后生存质量评分进行对比分析。结果 :经治疗,联合组的治疗总有效率为85.71%,明显高于单纯手术组的57.14%,差异具有统计学意义;联合组的术后8、16个月复发率分别为4.76%、9.52%,均明显低于单纯手术组的33.33%、38.10%,差异具有统计学意义;经治疗,联合组的生存质量为(74.36±3.21)分,明显高于对照组的(66.23±2.36)分,差异具有统计学意义。结论 :对颈腰部侵袭性纤维瘤病患者应用手术结合新辅助化疗治疗,可显著提高治疗效果,降低复发率,提高生存质量,值得推广。
Objective: To study the clinical effects of surgery and neoadjuvant chemotherapy in the treatment of cervical and lumbar invasive fibromatosis. Methods: Twenty-one patients with neck-lumbar invasive fibromatosis undergoing surgery in our hospital from August 2012 to June 2013 were selected as the only operation group (surgery only), and the other from August 2013 to June 2014 Twenty-one patients with cervical and lumbar invasive fibromatosis treated in our hospital were treated with combined neoadjuvant chemotherapy. The patients in both groups were followed up for 20 months. The two groups of clinical efficacy, relapse, before and after treatment quality of life scores were compared. Results: After treatment, the total effective rate of the combined group was 85.71%, which was significantly higher than that of the pure operation group (57.14%), the difference was statistically significant. The recurrence rates of the combined group were 4.76% and 9.52 %, Respectively, which were significantly lower than 33.33% and 38.10% respectively in the operation group. The quality of life in the combined group was (74.36 ± 3.21) points, which was significantly higher than that in the control group (66.23 ± 2.36) points , The difference was statistically significant. Conclusion: The surgical treatment of neoadjuvant chemotherapy in patients with cervical and lumbar invasive fibromatosis can significantly improve the therapeutic effect, reduce the recurrence rate and improve the quality of life, which deserves promotion.