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目的 了解IgA肾病临床和病理特点及其与预后的关系。方法 观察 72例经肾活检确诊为IgA肾病患者的临床表现、实验室检查、病理改变、免疫荧光与转归的关系。结果 患者常见的表现有高血压、肉眼或镜下血尿、蛋白尿、氮质血症 ,病理改变多样 ;治疗后 2 2例完全缓解 ,15例部分缓解 ,2 5例呈持续肾病性蛋白尿 ,10例发展为肾功能衰竭 ;其转归与临床表现、蛋白尿的程度、肾小球病理改变、免疫球蛋白沉积的部位显著的相关。结论 IgA肾病预后与病理特点、免疫发病机制有关。
Objective To understand the clinical and pathological features of IgA nephropathy and its relationship with prognosis. Methods 72 patients with renal biopsy confirmed IgA nephropathy clinical manifestations, laboratory tests, pathological changes, the relationship between immunofluorescence and outcome. Results The common manifestations were hypertension, macroscopic or microscopic hematuria, proteinuria, azotemia and pathological changes. After treatment, 22 cases were completely relieved, 15 cases partially relieved, 25 cases were persistent nephrotoxic proteinuria, 10 cases developed into renal failure; its outcome was significantly associated with clinical manifestations, the level of proteinuria, pathological changes of glomeruli and the deposition of immunoglobulin. Conclusion The prognosis of IgA nephropathy is related to the pathological features and immune pathogenesis.