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本文观察78例脑动脉硬化症患者与对照组44例,对其血清载脂蛋白E(APOE)和高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、胆固醇(TC)、甘油三脂(TG)、载脂蛋白AI(APOAI)、载脂蛋白B(100)(APOB(100))进行含量测定,并将APOE与HDL-C、LDL-C、TC、TG、APOAI、APOB(100)逐一进行相关比较,结果发现:脑动脉硬化症病人(CAS)血清APOE、LDL-C、TC、TG、APOB(100)明显高于正常对照组(P<0.01),HDL-C显著低于正常对照组(P<0.01),APOAI无明显变化(P>0.05),且APOE与HDL-C呈负相关;与LDL-C、TC、TG、APOB(100)呈正相关;与APOAI无直线相关关系。提示APOE可做为诊断脑动脉硬化症的重要指标。
In this study, 78 patients with cerebral arteriosclerosis and 44 control subjects were enrolled in this study. Serum apolipoprotein E (APOE), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), cholesterol , Triglyceride (TG), apolipoprotein AI (APOAI), apolipoprotein B (100) (APOB (100) , APOB (100). The results showed that APOE, LDL-C, TC, TG and APOB (100) in patients with cerebral arteriosclerosis were significantly higher than those in normal controls (P <0.01) HDL-C was significantly lower than that of normal control group (P <0.01), APOAI had no significant change (P> 0.05), and APOE was negatively correlated with HDL-C; 100); no correlation with APOAI Off relationship. Tip APOE can be used as an important indicator of diagnosis of cerebral arteriosclerosis.