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目的:评价辛伐他汀对冠状动脉粥样硬化性心脏病患者血浆N端脑利钠肽(NT-proBNP)水平的影响。方法:随机选取冠状心病患者40例为治疗组,常规治疗基础上给予辛伐他汀20mg,每晚顿服;另40例冠心病患者为对照组,仅给予常规治疗。于治疗前、治疗后8周分别测定N端脑利钠肽。结果:两组患者治疗前后NT-proBNP水平比较,差异有统计学意义(P<0.01)。结论:辛伐他汀可以显著降低冠心病患者NT-proBNP水平,改善心功能。
Objective: To evaluate the effect of simvastatin on plasma N-terminal pro brain natriuretic peptide (NT-proBNP) level in patients with coronary atherosclerotic heart disease. Methods: Forty patients with coronary heart disease were selected randomly as the treatment group. Simvastatin 20 mg was given on a routine basis and served overnight. The other 40 patients with coronary heart disease were treated as control group. N-terminal brain natriuretic peptide was measured before treatment and 8 weeks after treatment. Results: There was significant difference in NT-proBNP levels between the two groups before and after treatment (P <0.01). Conclusion: Simvastatin can significantly reduce the level of NT-proBNP in patients with coronary heart disease and improve cardiac function.