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目的探讨2型糖尿病合并冠心病者血清中诱骗受体3(DcR3)水平升高的临床意义。方法采用病例对照分析方法收集单纯冠心病组56例及2型糖尿病合并冠心病组65例作为研究对象。分别进行体格检查和实验室指标检测,采用酶联免疫吸附(ELISA)法检测血清中DcR3水平。结果与单纯冠心病组比,2型糖尿病合并冠心病组体质指数(BMI)、收缩压(SBP)、舒张压(DBP)明显升高,差异有统计学意义(P<0.05),甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、谷氨酰转肽酶(GGT)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1C)、血清DcR3含量明显增高,差异有统计学意义(P<0.05或P<0.01);冠心病组血清DcR3含量为(0.91±0.43)ng/ml,糖尿病组血清DcR3含量为(1.92±1.04)ng/ml,差异有统计学意义(t=4.12,P<0.01)。结论 SBP、LDL-C、2 h PG、HbA1C、DcR3为2型糖尿病合并冠心病患病的危险因素,DcR3可能是2型糖尿病合并冠心病新的预测因子和治疗靶点。
Objective To investigate the clinical significance of elevated levels of decoy receptor 3 (DcR3) in patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods 56 cases of simple coronary heart disease group and 65 cases of type 2 diabetes mellitus combined coronary heart disease group were collected by case-control analysis. Physical examination and laboratory test were performed respectively. Serum DcR3 level was detected by enzyme-linked immunosorbent assay (ELISA). Results Compared with CHD group, BMI, SBP and DBP of type 2 diabetes mellitus were significantly higher than those of CHD group (P <0.05), triglyceride (TG), low density lipoprotein cholesterol (LDLC), glutamyl transpeptidase (GGT), fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h PG) and glycosylated hemoglobin (HbA1C) (0.91 ± 0.43) ng / ml in coronary heart disease group and 1.92 ± 1.04 ng / ml in diabetic group (P <0.05 or P <0.01), the difference was statistically significant Statistical significance (t = 4.12, P <0.01). Conclusion SBP, LDL-C, 2 h PG, HbA1C and DcR3 are the risk factors of type 2 diabetes mellitus with coronary heart disease. DcR3 may be a new predictor and target of type 2 diabetes mellitus with coronary heart disease.