采用Ｌａｎｇｅｎｄｏｒｆ离体大鼠心脏灌注，研究全心缺血１０分钟、再灌注１５分钟后心肌细胞内Ｃａ２＋、丙二醛（ＭＤＡ）含量，冠脉流出液中乳酸脱氢酶（ＬＤＨ）含量以及心肌形态学改变。进而观察盐酸氟桂嗪（ＦＮＺ）和／或维生素Ｃ（ＶｉｔＣ）对上述各指标的影响。结果显示：再灌注１５分钟时ＦＮＺ＋ＶｉｔＣ组、ＶｉｔＣ组和ＦＮＺ组的心肌细胞内Ｃａ２＋含量无显著性差异（Ｐ＜００５），但心肌细胞内ＭＤＡ含量以及冠脉流出液中ＬＤＨ含量均比对照组低（Ｐ＜００５和＜００１），形态学改变也比对照组轻，ＦＮＺ和ＶｉｔＣ联用时效果更显著。由此表明，ＦＮＺ和ＶｉｔＣ均可通过抑制细胞内钙超载和氧自由基损伤而减轻再灌注损伤，两药联用的效果相当于两药单独作用之和 Cardiac perfusion of Langendorf rats was used to study the changes of intracellular Ca2 +, malondialdehyde (MDA) content in myocardial cells and the level of lactate dehydrogenase (LDH) in myocardial effusion after myocardial ischemia for 10 minutes and 15 minutes after reperfusion. Morphological changes. Furthermore, the effects of flunarizine hydrochloride (FNZ) and / or vitamin C on the above indexes were observed. The results showed that there was no significant difference in intracellular Ca2 + content between FNZ + VitC group, VitC group and FNZ group at 15 minutes after reperfusion (P <005), but the content of MDA in myocardium and the content of LDH in coronary effusion The control group was lower (P <005 and <001), and the morphological changes were also lighter than the control group. The combination of FNZ and VitC was more effective. Thus, FNZ and VitC can reduce reperfusion injury by inhibiting intracellular calcium overload and oxygen free radical damage, the combined effect of the two drugs is equivalent to the sum of the two drugs alone