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新型隐球菌仅有培养基上菌株超微结构的检查,而直接电镜检查脑背液(CSF)中的新型隐球菌尚未见有报告。本文报告一例SLE患者因每日服80mg强的松龙4个月,结果并发了新型隐球菌脑膜炎,乃对其(CSF)中的隐球菌作了透射电镜检查,并与直接涂片及培养的菌相比较。取患者治疗(以两性霉素B20mg/d及5-氟胞嘧啶800mg/d)前及治疗后的10及20天CSF沉淀物分别作镜检、培养及电镜观察。并以培养基上生长的菌作电镜观察对照。结果:直接镜检:治疗前可见到大量菌,呈球形,外围以
Cryptococcus neoformans has only ultrastructural examination of strains on culture medium, and no direct or indirect examination of Cryptococcus neoformans in CSF has been reported. This article reports a case of patients with SLE daily 80mg prednisolone for 4 months, the results of concurrent cryptococcal meningitis, cryptococcal (CSF) was made by transmission electron microscopy and direct smear and culture Compared to the bacteria. The patients were treated with amphotericin B20mg / d and 5-fluorocytosine 800mg / d before and after treatment and 10 and 20 days CSF sediment were microscopic examination, culture and electron microscopy. The growth of bacteria on the medium for electron microscopy control. Results: direct microscopic examination: before treatment can see a large number of bacteria, spherical, peripheral to