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目的 探讨稀硫酸和无水乙醇兔VX2肝肿瘤内注射的临床价值。方法 移植性VX2肿瘤兔 16只 ,随机分为稀硫酸和无水乙醇组 ,分别于肿瘤内注射 10 %稀硫酸和无水乙醇各 0 .5ml。结果 兔移植性VX2肿瘤内分别注射 10 %稀硫酸和无水乙醇各 0 .5ml,2 4h后 ,稀硫酸组肿瘤坏死率大于乙醇组 (P <0 .0 5 )。电镜观察肿瘤细胞表现为变性 ,坏死及凋亡改变。MRI扫描肿瘤术前T1WI、T2WI和T2DWI分别表现为均匀低信号、高信号和高信号 ,边界清楚 ;术后表现为混杂不均匀信号。肿瘤凝固性坏死在T1WI和T2WI上表现为高信号和稍低信号 ,增强时病灶无明显强化。结论 稀硫酸是一种新型肿瘤细胞灭活物质 ,经皮硫酸注射疗法创伤小 ,无明显副作用 ,可成为肝癌治疗的一种新方法。
Objective To investigate the clinical value of intravenous injection of dilute sulfuric acid and ethanol-free rabbit VX2 liver tumor. Methods Twenty-six transplanted VX2 tumor rabbits were randomly divided into dilute sulfuric acid and ethanol group, and were respectively injected with 0.5 ml of 10% diluted sulfuric acid and absolute ethanol in the tumor. Results Tumor necrosis rate in dilute sulfuric acid group was significantly higher than that in ethanol group (P <0.05) after injection of 0.5ml 10% dilute sulfuric acid and absolute ethanol respectively in 24 hours after transplanted VX2 tumor. Electron microscopy showed tumor cells showed degeneration, necrosis and apoptosis. MRI scan of tumor preoperative T1WI, T2WI and T2DWI showed uniform low signal, high signal and high signal, the border clear; postoperative heterogeneous heterogeneous signals. Tumor coagulation necrosis in the T1WI and T2WI showed high signal and slightly lower signal, enhanced lesions did not significantly enhanced. Conclusion Dilute sulfuric acid is a new kind of tumor cell inactivation substance. Percutaneous injection of sulfuric acid is less invasive and has no obvious side effects. It can be used as a new method for the treatment of liver cancer.