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本病是一种较常见的出血性疾病,多发生于儿童和青年。其临床特征为血小板减少性出血,血小板少于10万/毫米~(3);骨髓内巨核细胞正常或增多;不伴有其他血小板减少性疾病;脾脏不肿大或偶可触及。本病的病因和发病机理至今虽尚未完全清楚,但近年来的研究认为它是一种与免疫有关的疾病。患者血清中存在着抗血小板抗体(血小板凝集素),它是一种IgG,当这种抗体复被于血小板表面时,血小板即易被脾或肝破坏而使血小板存活时间缩短,因而导致血小板减少。由于血小板减少,在出血时IgG免疫抗体的增加,血小板在体内存活
The disease is a more common hemorrhagic disease, mostly in children and young people. The clinical features of thrombocytopenic hemorrhage, platelets less than 100,000 / mm ~ (3); normal or increased bone marrow megakaryocytes; not associated with other thrombocytopenia diseases; spleen is not enlarged or even palpable. The etiology and pathogenesis of this disease has not yet fully understood, but in recent years the study that it is an immune-related diseases. There is an anti-platelet antibody (thromboglobulin) in the patient’s serum, an IgG that is readily destroyed by the spleen or the liver when the antibody is re-applied to the platelet surface, shortening platelet survival and resulting in thrombocytopenia . Due to thrombocytopenia, an increase in IgG immunoglobulin at the time of bleeding, platelets survive in the body