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将我院于2006年10月-2011年10月收治的92例肥胖2型糖尿病患者随机均分成二甲双胍单独用药组和黄连素联合二甲双胍治疗组,均治疗12周,检测、分析治疗前后C-反应蛋白、空腹血糖、空腹血清C肽、餐后2h血糖、餐后2h血清C肽、体重指数、血脂等。结果:治疗组治疗后C-反应蛋白、空腹血糖、空腹血清C肽、餐后2h血糖、餐后2h血清C肽、体重指数、血脂等水平与治疗前及对照组治疗后比较明显下降(P<0.05)。结论:黄连素联合二甲双胍治疗肥胖2型型糖尿病患者可减少慢性炎症反应、降低体重指数及改善胰岛B细胞功能、降脂,其临床疗效明显优于对照组。
92 patients with obese type 2 diabetes mellitus admitted to our hospital from October 2006 to October 2011 were randomly divided into metformin alone group and berberine combined with metformin treatment group, were treated for 12 weeks, detection, analysis of C-response before and after treatment Protein, fasting blood glucose, fasting serum C-peptide, 2h postprandial blood glucose, 2h postprandial serum C-peptide, body mass index, lipids and so on. Results: The levels of C-reactive protein, fasting blood glucose, fasting serum C-peptide, 2h postprandial blood glucose, 2h postprandial serum C-peptide, body mass index and serum lipids in the treatment group decreased significantly compared with those before treatment and in the control group <0.05). Conclusion: Berberine combined with metformin can reduce the chronic inflammation, reduce the body mass index, improve the function of islet B cells and reduce the lipid in obese type 2 diabetic patients. The clinical curative effect is obviously better than that of the control group.