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目的：观察替硝唑治疗细菌性阴道疾病（ＢＶ）的疗效。方法：细菌性阴道疾病７６例，随机分Ａ组４０例，首次口服替硝唑２ｇ，以后每２４ｈ服１ｇ，共７ｄ。Ｂ组为对照组３６例，用２％克林霉素阴道霜每晚睡前放置５ｇ，共７ｄ。另有并发泌尿系感染的ＢＶ４４例，其中２０例用替硝唑治疗的为Ｃ组，方法同Ａ组，２４例为Ｄ组，是在Ｂ组治疗的基础上加服诺氟沙星０．１ｇ，ｐｏ，ｔｉｄ。结果：Ａ和Ｂ组总有效率分别为９８％和６９％，Ｐ＜０．０１。Ｃ和Ｄ组总有效率分别为９０％和５４％，Ｐ＜０．０１。结论：替硝唑对单纯性ＢＶ和合并泌尿系感染的ＢＶ均有较好的疗效，仅有少数病人出现不良反应。
Objective: To observe the efficacy of tinidazole in the treatment of bacterial vaginosis (BV). Methods: 76 cases of bacterial vaginosis were randomly divided into group A 40 cases, the first oral tinidazole 2g, after every 1h 24h, a total of 7d. B group as control group, 36 cases, with 2% clindamycin vaginal cream placed 5g every night before going to bed, a total of 7d. Another BV44 cases of urinary tract infection, of which 20 cases were treated with tinidazole for the C group, the same method as group A, 24 cases of group D, is based on the treatment of group B plus norfloxacin 0. 1g, po, tid. Results: The total effective rates in groups A and B were 98% and 69%, respectively, P <0.01. The total effective rates in groups C and D were 90% and 54%, respectively, P <0.01. Conclusion: Tinidazole has a good curative effect on BV and BV combined with urinary tract infection, and only a few patients have adverse reactions.