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目的探讨布地奈德联合阿奇霉素治疗小儿支原体肺炎的临床疗效及其对患儿炎性因子的影响。方法选取2012年10月—2017年1月于漳浦县医院儿科收治的支原体肺炎患儿90例,按照随机数字表法分为对照组和观察组,各45例。对照组患儿采用阿奇霉素治疗,观察组患儿在对照组基础上联合布地奈德雾化吸入治疗,两组患儿均以21 d为一个治疗疗程。比较两组患儿退热时间、咳嗽消失时间及住院时间;治疗前后炎性因子[肿瘤坏死因子α(TNF-α)、白介素10(IL-10)];临床疗效。结果观察组患儿退热时间、咳嗽消失时间及住院时间均短于对照组(P<0.05)。治疗前,两组患儿TNF-α、IL-10水平比较,差异无统计学意义(P>0.05);治疗后,观察组患儿TNF-α水平低于对照组,IL-10水平高于对照组(P<0.05)。观察组患儿临床疗效优于对照组(P<0.05)。结论采用布地奈德联合阿奇霉素治疗小儿支原体肺炎的临床疗效显著,可更好地改善机体炎性指标,促进疾病快速恢复。
Objective To investigate the clinical efficacy of budesonide combined with azithromycin in the treatment of children with mycoplasma pneumonia and its impact on inflammatory factors in children. Methods Ninety children with Mycoplasma pneumonia admitted in Zhangpu County Hospital from October 2012 to January 2017 were randomly divided into control group and observation group according to random number table method, 45 cases in each group. The children in the control group were treated with azithromycin, and the children in the observation group were treated with budesonide inhalation on the basis of the control group. Both groups were treated for 21 days with 21 d treatment. The antipyretic time, cough disappearing time and hospital stay in both groups were compared. The levels of inflammatory cytokines TNF-α and IL-10 before and after treatment were compared. Results The observation group patients with fever, cough disappear time and hospital stay were shorter than the control group (P <0.05). Before treatment, there was no significant difference in TNF-α and IL-10 levels between the two groups (P> 0.05). After treatment, the level of TNF-α in the observation group was lower than that in the control group, and the level of IL-10 was higher Control group (P <0.05). The clinical efficacy of the observation group was better than that of the control group (P <0.05). Conclusion The clinical efficacy of budesonide combined with azithromycin in the treatment of children with mycoplasma pneumonia is significant, which can better improve the body inflammatory index and promote the rapid recovery of the disease.